NAME (w/degree): Tony T. Yang, M.D., Ph.D.
ACADEMIC TITLE: Assistant Professor, In Residence
E-MAIL ADDRESS: tyang@ucsd.edu
PHONE #: (858) 966-5832
FAX #: (858) 966-6733.
ACADEMIC PROFILE:
Biography (100 words)
Tony Yang was born in Texas. He graduated Phi Beta Kappa from The Johns Hopkins University in 1985. Following his undergraduate education, he attended U.C. San Diego in the Medical Scientist Training Program (MSTP). He obtained his Ph.D. in the lab of Dr. Floyd Bloom at The Scripps Research Institute. His Ph.D. thesis focused on applying Magnetoencephalography (MEG) to examine neural plasticity and somatosensory cortical reorganization in upper limb amputees and brachial avulsion patients. Upon finishing the M.D.-Ph.D. program at UCSD in 1996, he entered and completed an internship and adult psychiatry residency program at Stanford University. Following completion of residency, he entered a three-year combined Child and Adolescent Psychiatry Fellowship and NIMH T32 post-doctoral research training program at Stanford University. In 2002, he graduated from Stanford University and took a position at UCSD. At present, he is an Assistant Professor, In Residence, within the Child and Adolescent Psychiatry Division in the Department of Psychiatry at the UCSD School of Medicine.
Research Focus (100 words)
Dr. Yang’s research focus is on the study of adolescent depression using functional Magnetic Resonance Imaging (fMRI). He has support for his research from the NARSAD foundation, the Klingenstein Third Generation Foundation, and NIMH. He has a 5-year NIMH Career Development Award (K23) from NIMH to study adolescent depression using functional MRI.
Clinical Focus (100 words)
Dr. Yang is a child and adolescent psychiatrist working at Children’s Plaza in the outpatient psychiatry clinic. He is the physician leader on two treatment teams at Children’s Plaza, supervisor of the child and adolescent psychiatry fellows, and primary psychiatrist for his patients at Children’s Plaza. Dr. Yang’s primary clinical focus is on the understanding and treatment of depression in children and adolescents. Dr. Yang has started a Cognitive Behavioral Therapy for Depressed Adolescents at Children's Plaza (Please see description of CBT program below).
Selected Publications (5)
1. Yang, T.T., Gallen, C.C., Schwartz, B.J., Bloom, F.E.. Non-Invasive Somatosensory Homunculus Mapping in Humans Using a Large Array Biomagnetometer. The Scripps Research Institute, La Jolla, CA. Proc. Natl. Acad. Sci. USA. Vol. 90, pp. 3098-3102, April 1993.
2. Yang, T.T., Gallen,, C.C., Bloom, F.E., Ramachandran, V., Cobb, S. Noninvasive Detection of Cerebral Plasticity in Adult Human Somatosensory Cortex. The Scripps Research Institute & University of California, San Diego. Neuroreport. Vol. 5, pp. 701-704. February, 1994.
3. Yang, T.T., Gallen,, C.C., Bloom, F.E., Ramachandran, V., Cobb, S. .Sensory Maps in the Human Brain. The Scripps Research Institute & University of California, San Diego. Nature. Vol. 368, no. 6472, pp. 592-593 . April 14, 1994.
4. Yang, T.T., Menon, V., Eliez, S., Blasey, C., White, C., Gotlib, I.H., Reiss, A.L. Amygdalar Activation Associated with Positive and Negative Facial Expressions: A 3T Functional Magnetic Resonance Imaging Experiment. Neuroreport, 2002, Oct. 7; 13(14): 1737-41. *
Yang, T.T., Menon, V., Gotlib, I.H., Reid, A. J., Reiss, A.L. Amygdalar activation associated with happy facial expressions in adolescents: a 3-T functional MRI study Journal of the American Academy of Child and Adolescent Psychiatry, 2003 Aug;42(8):979-85.
Cognitive Behavioral Therapy (CBT) for Depressed Adolescents Program at Children's Plaza.
Due to the fairly recent FDA Black Box warnings regarding the use of antidepressants in children and adolescents, it has become significantly more difficult to prescribe and monitor the use of antidepressants in depressed adolescents. Furthermore, due to the media coverage of the FDA Black Box warnings, parents are much more aware and are often concerned about the possible side effects of antidepressants being used in their adolescents. In order to meet the needs of adolescents and parents who want an alternative treatment to antidepressants for the treatment of depression, I have organized some of the psychology interns and child and adolescent fellows to do CBT on adolescents suffering from depression. Adolescents suffering from depression who do NOT want to use antidepressants initially for treatment may be referred to our clinic for CBT treatment. After being referred to us, we will first do a comprehensive interview to determine the adolescent's DSM-IV diagnosis. The KSADS-PL (the gold standard in child and adolescent psychiatry for determining psychiatric diagnosis) will be administered to the adolescent and the parent(s). If the adolescent has depression, then he/she will receive CBT. If the adolescent does not have depression, then he/she and the parents will be given the results of the KSADS-PL which will inform them of the adolescent's psychiatric diagnosis. For Medi-Cal patients, our clinic will accept their Medi-Cal insurance. For commercial/private insurance patients, they may be seen by our clinic for a very reasonable rate of $25 per session. Each session lasts 50-60 minutes. Since they will be seen by trainees in our clinic, the commercial/private insurance patients will simply need to sign a waiver form that states they agree to be seen by a trainee in our clinic at Children's Plaza. Please note that the "trainees" that they will be seeing are actually quite advanced in their training. The psychology interns have received a great deal of training in CBT and using instruments such as the KSADS-PL to make a psychiatric diagnosis. The psychology interns in our program already have their Masters degrees, and they are in their final year of training just prior to receiving their Ph.D. Similarly, the Child and Adolescent Psychiatry fellows have already completed their internship and general psychiatry residency prior to entering our fellowship program. The adolescent that will most likely benefit the greatest from the CBT program will be those suffering from Major Depression (MDD) and/or Dysthymia, and who do not have any other comorbid psychiatric or neurological disorders.
If there are any adolescents with depression who do NOT wish to initially use antidepressants and desire to receive Cognitive Behavioral Therapy, please contact me directly on my confidential voicemail at Children's Plaza: (858) 966-5832 ext. 7761.
CURRICULUM VITAE
Office Address: 3020 Children’s Way
MC-5018
San Diego, CA 92123
Office Fax: (858) 966-6733
Office Telephone: (858) 966-5832 extension 7761
E-mail: tyang@ucsd.edu
Citizenship: United States
Education:
1985 The Johns Hopkins University B.A. Natural Sciences
Baltimore, MD. Phi Beta Kappa.
1994 University of California, San Diego Ph.D. Molecular Pathology
School of Medicine
1996 University of California, San Diego M.D.
Postdoctoral Training:
1996-97 Internship
Stanford Hospital
Stanford, CA
Department of Psychiatry
Stanford, CA
1999-02 Child and Adolescent Fellow
Stanford University
Stanford, CA
2000-02 NIMH T32 Research Fellow
Stanford University
Child and Adolescent Psychiatry
Stanford, CA
1982 Genetic and Cloning Lab: Mechanisms of Gene Amplification. Dr. S. Fogel. University of California, Berkeley, Berkeley, CA.
1984–85 Neural Network Modeling of Learning and Vision using the Boltzmann Machine. Dr. Terrence J. Sejnowski. The Johns Hopkins University, Baltimore, MD.
1988 Event Related Potential Studies of Language in Infants and in Children with Williams Syndrome. Dr. H. Neville and Dr. U. Bellugi. The Salk Institute, La Jolla, CA.
1989 Molecular Cell Biology Lab: Human Genome Mapping. Dr. G. Evans. The Salk Institute, La Jolla, CA.
1990 Event Related Potential and MEG Studies of Selective Attention in Humans. Dr. Steven Hillyard and Dr. Floyd Bloom.
University of California, San Diego & The Scripps Research Institute, La Jolla, CA.
Working Experience:
12/01/04-Present Assistant Professor, In Residence
University of California, San Diego School of Medicine
Department of Psychiatry
Division of Child and Adolescent Psychiatry
9500 Gilman Drive
La Jolla, CA 92037-0603
2002-11/30/04 Assistant Clinical Professor, Non-salaried
University of California, San Diego School of Medicine
Department of Psychiatry
Division of Child and Adolescent Psychiatry
9500 Gilman Drive
La Jolla, CA 92037-0603
2002-Present Child and Adolescent Psychiatrist
Children’s Plaza, Children’s Hospital
Child and Adolescent Psychiatry Outpatient Clinic
UCSD, Division of Child and Adolescent Psychiatry
3020 Children's Way, Mail Code: 5018
San Diego, CA 92123-4282
2002-2003 Child and Adolescent Psychiatrist
Riley Special Education School
Center for students with serious emotional and behavioral problems UCSD, Division of Child and Adolescent Psychiatry
5650 Mt. Ackerly Dr.
San Diego, CA 92111
2003 Child and Adolescent Psychiatrist
Chadwick Center, Children’s Hospital
Center for Abused Children and Adolescents
UCSD, Division of Child and Adolescent Psychiatry
3020
Children's Way, MC 5016
San Diego, CA 92123
1999-2002 Child and Adolescent Fellowship
Stanford University, Stanford, CA
Training experience:
u 6 months inpatient Eating Disorders unit with additional outpatient clinic evaluations for eating disorders.
u 6 months outpatient consultation in pediatric child and adolescent clinic at Stanford.
u 6 months inpatient consultation and liaison work at Lucile Salter Packard Children’s Hospital at Stanford, including extensive experience on a medical/psychiatric unit, pain clinic consultations, bone marrow inpatient unit consultations, neurology/EEG clinic consultations for psychogenic seizures, outpatient consultations for PDD, anxiety disorders, and schizophrenia.
u 2 years of call duty including Stanford ER consultations and admissions along with consultation for Lucile Salter Packard Children’s Hospital inpatient units and outpatient clinics.
u 2 years of psychodynamic psychotherapy training with long-term therapy patients.
u 1 year in Mood Disorders outpatient clinic (depressed and bipolar children and adolescents) at Stanford. Training focused on pharmacological treatment of children and adolescents with mood disorders.
u 1 year in Child and Adolescent outpatient clinic at Kaiser, Santa Clara, CA with special training emphasis in infant-mother evaluations and ADD/ADHD along with seeing patients with PDD, substance abuse/dependence, mood and anxiety disorders.
1996-1999 Adult Psychiatry Residency
Stanford University, Stanford, CA
Training experience:
u 4 months inpatient medicine including ICU/CCU and step-down unit experience.
u 2 months inpatient neurology including acute stroke unit, epilepsy ward with 24-72 hour video-EEG, and general neurology/oncology experience.
u 13 months of inpatient psychiatry including acute locked units and open units at the Palo Alto Veterans Administration (VA) and Stanford Hospital.
u 4 months geriatric psychiatry inpatient experience at Stanford Hospital.
u 4 months of Consultation and Liaison experience at the Palo Alto Veterans Administration and Stanford Hospital.
u 2 years training in Cognitive Behavioral Therapy (CBT) and Psychodynamic psychotherapy with long-term therapy patients.
u 6 months outpatient clinic experience at Cowell Student Health Services at Stanford University (Stanford undergraduate, graduate, medical, law, and business school students) with training emphasis on brief, short-term psychotherapy.
u 6 months training at the Stanford Psychopharmacology Outpatient Clinic with special training/supervision in mood disorder/depression, OCD, and bipolar affective disorder.
u 3 years of call experience including ER admissions, ER and hospital consults at both the Palo Alto Veterans Administration and Stanford Hospital.
1990-1992 Consultant
Biomagnetic Technologies, Inc (BTi)
Helped with design and implementation of clinical applications (pre-surgical functional mapping) for magnetoencephalography (MEG).
1983-84 Organizer
Johns Hopkins University: Chaplain’s Office
Responsible for going to inner-city children’s homes and interviewing/testing children, recruiting and training tutors, making sure tutorial program runs smoothly and properly.
1983 Tutor
Johns Hopkins University
Hired by Johns Hopkins to tutor freshmen who were failing physics and calculus courses after their midterm.
Honors and Awards:
1982 Hodson-Beneficial Merit Scholarship
Johns Hopkins University
1985 Phi Beta Kappa
Johns Hopkins University
1985 B.A. awarded with “General Honors”
Johns Hopkins University
1987 Medical Scientist Training Program
(MSTP) U.C. San Diego
1989 NIMH Fellowship
The Scripps Research Institute & U.C. San Diego
1990 McDonnell-Pew Foundation Fellow
The Scripps Research Institute & U.C. San Diego
1998 NIMH Outstanding Resident of the Year
Ranked #1 in the U.S. and Canada
1999 APA Program for Minority Research
Training in Psychiatry Mini-Fellowship
American College of Neuropsychopharmacology (ACNP)
Annual Meeting
2000-01 Wisconsin Symposium
Health Emotions Research Institute Scholar
2001 Eli Lilly Pilot Research Award
American Academy of Child and Adolescent Psychiatry (AACAP)
2003 Klingenstein Third Generation Foundation Award
2003 NARSAD Young Investigator Award
2004 Clinical Trials in Psychopharmacology Fellowship
American Society of Clinical Psychopharmacology (ASCP)
Annual Meeting
Licensure:
1997-Present California medical license
Certification:
2002 Board Eligible, Child & Adolescent Psychiatry
2004 Diplomate, American Board of Psychiatry and Neurology Certificate # 53509
Presentations:
2002 Functional Magnetic Resonance Imaging of the Amygdala in Adults and Adolescents. Grand Rounds. Children’s Hospital, San Diego, CA. Dec. 2002.
2003 Amygdalar Activation Associated With Happy Facial Expressions in Adolescents: A 3-T Functional MRI Study. American Academy of Child and Adolescent Psychiatry Annual Meeting. Miami, Florida. Oct. 2003.
2003 The Application of Magnetoencephalography to the Study of Neural Plasticity and Cortical Reorganization in the Human Somatosensory Cortex. Grand Rounds. Children’s Hospital, San Diego, CA. Oct. 2003.
2004 The Psychopharmacological Management of Child and Adolescent Psychiatric Disorders. UCSD Continuing Medical Education Course. Workshop. October 07, 2004.
Grants:
2003-present NARSAD Young Investigator Award. $60,000 to use functional MRI to study adolescents with Major Depressive Disorder. July 1, 2003 - June 30, 2007
2003-2005 Klingenstein Third Generation Foundation. $30,000 to use functional MRI to study adolescents with Dysthymic Disorder. July 1, 2003 - June 30, 2005
2001-2003 American Academy of Child and Adolescent Psychiatry (AACAP) Pilot Research Award. $9,000 to apply functional MRI to examine amygdalar function in normal adolescents.
2005-present NIHM Patient-Oriented Research Career Development Award (K23)
$838,000 to apply functional MRI over 5 years to understand how the underlying neural circuitry is affected in adolescents suffering from depression.
Journal Reviewer:
2002-Present Journal of Affective Disorders
2003-Present Brain Research
Professional Memberships:
1993-1995 Society for Neuroscience
2001-Present American Academy of Child & Adolescent Psychiatry
2002-Present American Psychiatric Association
2002-2003 American Medical Association
2002-Present The Organization for Human Brain Mapping
Committees:
2002-present Child Psychiatry Residency Education Committee, UCSD
2002-present Residency Selection Committee in Child and Adolescent Psychiatry, UCSD
2003-Present Residency Selection Committee, UCSD
2003-Present Graduate Education Committee, Department of Psychiatry, UCSD
Teaching Experience:
2003-Present U. C. San Diego: School of Medicine. Lecturer to third year medical students on diagnosis and psychopharmacological treatment of childhood and adolescent psychiatric disorders.
2003-Present U. C. San Diego: School of Medicine. Lecturer to second year adult psychiatry residents on psychopharmacological treatment of childhood and adolescent psychiatric disorders.
2002-Present U.C. San Diego: Neurobiology Seminar Course. Lecturer to child and adolescent psychiatry fellows and adult psychiatry residents.
2002-Present U.C. San Diego: Children’s Plaza Team Leader. Teacher and Supervisor to child and adolescent psychiatry fellows, psychology interns, marriage and family social workers and trainees. Weekly meeting for two hours.
2002-Present U. C. San Diego: Individual Supervisor to first-and second-year child and adolescent psychiatry fellows training at Children’s Plaza Outpatient Psychiatry Clinic.
2001 Stanford University: Child and Adolescent Psychiatry Neuroscience Course. Lecturer to first year child fellows, “The Neurobiology of Depression.”
1999-Present Stanford University: Child and Adolescent Psychiatry. Mentor and reader for Stanford undergraduate senior honors thesis. Mentored Stanford undergraduate for over 2 years.
1996-2000 Stanford University: Stanford School of Medicine
Taught Stanford third and fourth year medical students rotating on psychiatry, neurology, and medicine.
1998 Stanford University: Lecture on diagnosis, prevention, and treatment of depression to Stanford first and second year medical students.
1983 Johns Hopkins University: Tutored physics and calculus to undergraduates at Johns Hopkins.
1982-85 Johns Hopkins University: Chaplain’s Office. Tutored inner city children in reading, writing, and math.
Lectures:
2005 U.C. San Diego. Functional Neuroimaging Methods in Child and Adolescent Psychiatry. Lecture to first and second year Child and Adolescent Psychiatry Fellows. Neuroscience Seminar. 02/15/2005.
Public Service:
2001 Lucille Packard Children’s Hospital, Stanford. Lecture to community parents and patients on “Stress and Depression.” .
2001 Palo Alto Unified High School District. Lecture to high school teachers, counselors, psychologists, nurses on the diagnosis and treatment of “Adolescent Depression.”
2000-2002 Stanford University: Asian American Mentoring Program. Mentor to Stanford undergraduates interested in medicine, psychiatry, or neuroimaging.
1982-85 Johns Hopkins University: Chaplain’s Office. Volunteer tutor for inner city children in Baltimore who were several years behind in reading, writing, and math.
Publications:
1. Yang, T. T., Gallen, C. C., Hampson, S., Bloom, F. E. Neuromagnetic Premotor Readiness Fields and Rhythmic Activity Alterations Preceding Speech. Society for Neuroscience. Abstract. 1990.
2. Yang, T. T., Gallen, C. C., Schwartz, B., Bloom, F. E. Intersubject Reliability of Neuromagnetic Measurements on the Human Somatosensory and Auditory Systems. Department of Neuropharmacology. The Scripps Research Institute, La Jolla, CA 92047. Society for Neurosciences Abstract. 1991.
3. Yang, T. T., Gallen, Schwartz, Bloom. Somatosensory Homunculus Mapping Using a Large Array Biomagnetometer. Western Neuroradiology. Abstract. 1992
4. Yang, T. T., Gallen, Schwartz, Bloom. Detailed Somatosensory Homunculus Mapping Using a Large Array Biomagnetometer. American Academy of Neurology Abstract. 1993
5. Yang, T. T., Gallen, C. C., Schwartz, B. J., Bloom, F. E. Preoperative Noninvasive Functional Somatosensory Mapping Using a Large Array Biomagnetometer. The Scripps Research Institute, La Jolla, CA. Congress of Neurological Surgeons (CNS) Abstract. 1993.
6. Yang, T. T., Gallen, C. C., Schwartz, B. J., Bloom, F. E. Detailed Somatosensory Homunculus Mapping in Humans Using a Large Array Biomagnetometer. The Scripps Research Institute. Ninth International Conference on Biomagnetism Paper and Abstract. 1993.
7. Yang, T. T., Gallen, Schwartz, Bloom. Noninvasive Study of Neural Plasticity in Adult Human Somatosensory System. The Scripps Research Institute. European Society for Neuroradiology. Abstract. 1993.
8. Yang, T. T., Gallen, Bloom, F. E., Neuromagnetic Study of Neural Plasticity in Adult Human Somatosensory System. The Scripps Research Institute. Western Neuro '93 Abstract. 1993.
9. Yang, T. T., Gallen, Ramachandran, Cobb, Bloom. Noninvasive Study of Neuroplasticity in Adult Human Somatosensory System. The Scripps Research Institute & U.C. San Diego. Society for Neuroscience Abstract. 1993.
10. Yang, T. T., Gallen, Ramachandran, Cobb, Schwartz, Bloom. Neuromagnetic Study of Neuroplasticity in Adult Human Somatosensory System. The Scripps Research Institute & U.C. San Diego. American Academy for Neurology (AAN) Abstract. 1993.
11. Yang, T. T., Gallen, Ramachandran, Cobb, Bloom. Magnetoencephalographic Evidence for Massive Cortical Reorganization in the Adult Human Central Nervous System. The Scripps Research Institute & U.C. San Diego. American Association for the Advancement of Science (AAAS) Abstract. 1993.
2003-2004 Eli Lilly:
1) A Double-Blind Study of Functional Outcomes with Atomoxetine-Hydrochloride and Placebo in Adult Outpatients with DSM-IV Attention-Deficit/Hyperactivity Disorder (B4Z-MC-LYBV). Sub-Investigator.
2003 Shire:
2005 AstraZeneca:
1) A 3-week, Multicenter, Double-blind, Parallel-group, Placebo-controlled Study of the Efficacy and Safety of Quetiapine Fumarate in the Treatment of Children and Adolescents with Acute Bipolar I Mania. Protocol number: D1441C00149. Principal Investigator.
2) A 6-week, Multicenter, Double-blind, Parallel-group, Placebo-controlled Study of the Efficacy and Safety of Quetiapine Fumarate in the Treatment of Adolescents with Schizophrenia. Protocol number: D1441C00112 Principal Investigator.
3) A 26-week, Multicenter, Open-label Study of the Safety and Tolerability of Quetiapine Fumarate in Children and Adolescents with Bipolar I Disorder and Adolescents with Schizophrenia. Protocol number: D1441C00150 Principal Investigator.
2005 Forest Labs: 1) A Double-Blind Flexible Does Study of Escitalopram in Pediatric Patient with Major Depressive Disorder. Protocol SCT-MD-32. IND Number: 58,380. Principal Investigator.
2) An Open-Label Extension Study of the Safety and Efficacy of Escitalopram in Pediatric Patients with Major Depressive Disorder. Protocol SCT-MD-32A. IND Number 58,380. Principal Investigator.